Wait—Does Ozempic Make You Tired? 

Wait—Does Ozempic Make You Tired?

The Ozempic (Semaglutide) jingle may be catchy, but if you’re taking the drug, you might find yourself craving more Zzzs instead. While the blood sugar and weight loss transformations are real, significant changes in your body can lead to both fatigue and increased energy. So, can Ozempic make you tired? Or, on the flip side, can Ozempic give you energy? 

Both scenarios can be true—Ozempic fatigue is real, as is the newfound energy you may notice. Here’s what you need to know about how Ozempic affects your energy levels and how to manage any fatigue you might experience. 

How Ozempic (and Other GLP-1s) Work 

Ozempic is part of a class of drugs known as GLP-1s (glucagon-like peptides). The body naturally produces GLP-1, and Ozempic works by stimulating the GLP-1 receptor in the brain and gastrointestinal tract. Though it is primarily approved for use in people with type 2 diabetes, Ozempic and similar drugs like Wegovy, which uses the same active ingredient (semaglutide), can help with weight loss by regulating food cravings, reducing appetite, and helping people feel full with less food. 

“Ozempic works by stimulating the GLP-1 receptor in the brain and the gastrointestinal tract,” says Dr. Ric S Kolluri (Hon.), CEO of Púr MedSpa. “They have a tremendous effect on satiety, shutting down appetite so the patient feels very full after eating much less food.” 

Why Ozempic Can Make You Tired 

While Ozempic offers several health benefits, fatigue can be an issue, especially in the first few months. “Fatigue can be an issue, especially in the first several months, because your body is working very hard to burn fat,” explains Dr. Sue Decotiis, MD, a NYC-based weight-loss doctor. “Your body’s whole physiological makeup is changing, so it’s normal to feel tired at first.” 

Dr. Libu Varughese, MD, an endocrinologist and the medical advisor at Aeroflow Diabetes, adds, “You are actively losing weight, then you may feel more tired due to reasons such as dehydration from losing water weight, or reduced calorie intake.” 

Why Ozempic Can Give You Energy 

Not everyone experiences fatigue with Ozempic. In fact, many people report feeling more energetic as they lose weight. “For the most part, when people start losing weight, they can also gain energy,” says Dr. Amy Lee, MD, the chief medical advisor at Lindora. “Carrying excessive weight can be very taxing for joints and results in overall inflammation, which could also cause one to feel tired and even fatigued.” 

Dr. Ali adds, “It is motivating to see results with these medications. Furthermore, as someone loses weight, it is easier to move around, and health issues will also improve.” 

Tips to Combat Ozempic Fatigue 

If you’re experiencing fatigue while on Ozempic, here are some tips to help manage it: 

  1. Stay Hydrated Dehydration is a common cause of fatigue. Ensure you drink plenty of water throughout the day to stay hydrated.
  2. Maintain a Balanced Diet Eating a balanced diet rich in vitamins, minerals, and protein can help maintain your energy levels. Avoid processed foods and focus on whole foods that provide sustained energy.
  3. Regular Exercise While it may seem counterintuitive, regular exercise can boost your energy levels and help combat fatigue. Start with light activities and gradually increase the intensity.
  4. Get Adequate Sleep Ensure you get enough sleep each night. Good sleep hygiene can significantly improve your energy levels and overall well-being.
  5. Monitor Your Blood Sugar Levels Keep an eye on your blood sugar levels and make adjustments to your diet and medication as needed. Speak with your healthcare provider if you have concerns.
  6. Consider Additional Treatments At Púr MedSpa, we offer various treatments that can complement your weight loss journey and help manage fatigue. These include IV drips for energy, B12 shots, and other wellness therapies that can boost your overall energy levels.

“IV drips and B12 shots can be very effective in combating fatigue and providing a much-needed energy boost,” says Hannah F., RN. “These treatments ensure your body gets the essential vitamins and nutrients it needs to function optimally.” 


Ozempic can affect individuals differently, leading to either fatigue or increased energy. Understanding how your body reacts and taking steps to manage any fatigue can help you make the most of this medication. At Púr MedSpa, we offer personalized care and advanced treatments to support your weight loss journey and overall wellness. Púr does not offer Ozempic but a compounded Semaglutide from FDA cleared Pharmacy.  

For more information or to schedule a consultation, visit our website at Púr MedSpa or call us at 469-750-2273. Your journey to better health and vitality starts here! 

Expert Sources Dr. Mir Ali, MD, a board-certified bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center FDA Approves New Drug Treatment for Chronic Weight Management, First Since 2014. FDA. Dr. Sue Decotiis, MD, an NYC-based weight-loss doctor Dr. Libu Varughese, MD, an endocrinologist and the medical advisor at Aeroflow Diabetes Dr. Amy Lee, MD, the chief medical advisor at Lindora 

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